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KMID : 1143520230110030114
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Journal of Korean Society of Oral Health Science
2023 Volume.11 No. 3 p.114 ~ p.119
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Effects of Combined Administration of Sulforaphane and Resveratrol on Orofacial Pain Control in Rats
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Park Min-Kyoung
Cheon Sae-Hee
Kim Kyung-Min
Kim Hye-Jin
Lee Min-Kyung
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Abstract
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Objectives: This study was designed to confirm the effects of natural products on the control of facial pain.
Methods: In this study, 5% formalin was injected into the face of the experimental animals to induce pain behavioral responses, and sulforaphane 15 g or 150 g/50 l and resveratrol 20 g or 200 g/50 l were pre-treated to confirm the pain control effects. μ μμ μ μμ
Results: The two drugs showed pain-modifying effects in a concentration-dependent manner. In addition, a significant analgesic effect was confirmed when the two drugs were co-administered at low concentrations.
Conclusions: Therefore, through this experiment, sulforaphane and resveratrol can be effective therapeutic agents for controlling orofacial pain
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KEYWORD
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Combined administration, Orofacial pain, Sulforaphane, Rat, Resveratrol
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